About marrow, blood and blood cells the information in this section about normal blood and marrow may help you understand the lymphoma information in the rest of this guide. We would like to show you a description here but the site wont allow us. Nccn guidelines index nhl table of contents discussion continue nccn clinical practice guidelines in oncology nccn guidelines non hodgkin s lymphomas version 2. Nccn clinical practice guidelines in oncology hodgkin. Non hodgkin lymphoma and hodgkin lymphoma are the two main types. The disease is defined in terms of its microscopic appearance histology see the image below and the expression of cell surface markers immunophenotype. Updates in treatment strategies for hodgkin lymphoma in. What are the nccn treatment guidelines for follicular. Target audience this initiative is designed to meet the needs of oncologists, hematologists, nurses, pharmacists, physician assistants, and other health care professionals. Clinical history depends on the type of lymphoma and stage at presentation. It explains which cancer tests and treatments are recommended by experts of hodgkin lymphoma. Lymphomas can affect any organ in the body, present with a wide range of symptoms, and be seen by primary care.
From basic information about cancer and its causes to indepth information on specific cancer types including risk factors, early detection, diagnosis, and treatment options youll find it here. The national comprehensive cancer network nccn makes no representations or warranties of any kind regarding their content, use or application and disclaims any responsibility for their application or use in any way. Current management of classical hl involves initial treatment with chemotherapy or combined modality therapy followed by restaging with petct to assess treatment response using the deauville criteria 5point scale. Nccn nonhodgkins lymphomas series peripheral tcell. In the united states in 20, about 9,290 persons were expected to be diagnosed with hodgkin lymphoma. What are the nccn guidelines for determining unfavorable factors for stage iii hodgkin lymphoma hodgkin disease. The nccn clinical practice guidelines in oncology for hodgkin lymphoma hl provide recommendations for the management of adult. Emerging treatment options for relapsedrefractory hodgkin lymphoma. Lymphoma is a group of malignant neoplasms of lymphocytes with more than 90 subtypes. Join robert chen, md from city of hope comprehensive cancer center for this nccn webinar presentation, emerging strategies in the upfront treatment of hodgkin lymphoma. Updates in treatment strategies for hodgkin lymphoma.
Burkitt lymphoma part 1 of 3 the selection, dosing, and administration of anticancer agents and the management of associated toxicities are complex. Non hodgkin s lymphoma includes all the other types of lymphoma. The nccn guidelines and this illustration may not be reproduced in any form without the express written permission of nccn. Diffuse large bcell lymphomas dlbcls and follicular lymphoma fl are the most common subtypes of bcell non hodgkin s lymphomas nhls in adults, accounting for approximately 30% and 22%, respectively, of all newly diagnosed nhls annually. What are the nccn guidelines on the diagnosis of burkitt. Hodgkin disease lymphoma nccn hodgkin disease lymphoma panel members. Drug dose modifications and schedule and initiation of supportive care interventions are often necessary because of expected toxicities and. Advancing oncology nursing nccn 2020 annual conference. Hodgkin lymphoma hl is one of the most frequent lymphomas in the western world, with an annual incidence of about 3 cases per 100,000 persons. Involvedsite radiation therapy isrt, 2430 gy, is the preferred treatment option for stage i or ii if. Diffuse large bcell lymphoma is the most common type of lymphoma.
This lymphoid malignancy involves peripheral lymph nodes and can also affect organs such as liver, lung, and bone marrow. Lymphoma is a general name for a group of cancers that affect the lymphatic system. Non hodgkin lymphoma sometimes called nhl, or just lymphoma is a cancer that starts in cells called lymphocytes, which are part of the bodys immune. New options for the management of hodgkin lymphoma nccn. Treatment is based on the histologic subtype and severity of sympt. Types of bcell lymphoma types of tcell lymphoma research and statistics. Download the pdf esmomagnitude of clinical benefit scale clinical practice guidelines slide. Nonhodgkin lymphoma stages american cancer society. Nonhodgkins lymphoma clinical practice guidelines in. It is traditionally classified broadly as non hodgkin or hodgkin lymphoma. The goal of this book is to help you get the best cancer treatment.
Peripheral tcell lymphomas ptcls represent a relatively uncommon heterogeneous group of non hodgkin s lymphomas nhls with an aggressive clinical course and poor prognosis. The international prognostic index ipi has been the basis for determining prognosis in patients with aggressive non hodgkin lymphoma nhl for the past 20 years. The national comprehensive cancer network makes no representations nor warranties of any kind whatsoever regarding their content, use, or application and disclaims any responsibility for their application or use in any way. About 40% of patients suffer from constitutional symptoms bsymptoms.
Nccn guidelines hodgkin lymphoma uw hematology protocols. Advani, md, saul rosenberg professor of lymphoma, stanford. In addition to its general guidance on diagnosis of lymphoma, the national comprehensive cancer network nccn recommends the following studies to establish a diagnosis of burkitt lymphoma ref29. Hodgkin lymphoma is defined by the presence of reedsternberg or related cells. Nccn clinical practice guidelines in oncology nccn.
James o armitage, randy d gascoyne, matthew a lunning, franco cavalli. Hollywood, florida there were several significant changes to the national comprehensive cancer network nccn hodgkin s disease guidelines announced at the seventh annual nccn conference see table for nccn member institutions. Identify novel therapeutic agents or regimens and how to incorporate them into the management of patients with advanced or relapsed or refractory hodgkin lymphoma. Practice guidelines in oncology hodgkins disease who archives. Advani, md stanford cancer institute disclosure of relevant financial relationships all faculty and activity planners participating in nccn continuing education activities are expected to disclose any relevant financial relationships with a commercial interest as defined by the accmes, anccs, and acpes standards for commercial support. Whether you or someone you love has cancer, knowing what to expect can help you cope. Nonhodgkin lymphoma symptoms, diagnosis and treatment.
Guidelines in oncology nccn guidelines for hl discuss the clinical management of patients with chl and nlphl, focusing on. Clinical staging for classic hodgkin lymphoma hodg2. The nccn and esmo offer similar treatment recommendations, as followsref19ref68. Peripheral tcell lymphoma is a type of non hodgkin s lymphoma. An enhanced international prognostic index nccnipi for. Current and emerging treatments for newly diagnosed patients and for patients with relapsed or refractory disease will also be explained. There are many types of tcells and thus, many tcell cancers. With the right treatment, at least 8 out of 10 people can be. After someone is diagnosed with non hodgkin lymphoma, doctors will try to figure out if it has spread, and if so, how far. The mission of nccn is to improve cancer care so people can live better lives. Hodgkin lymphoma hl is an uncommon malignancy involving lymph nodes and the lymphatic system.
Marrow is the spongy center inside of bones where blood cells are made. The two major types of lymphoma are hodgkin lymphoma hl and non hodgkin lymphoma nhl. Hodgkin lymphoma formerly, hodgkin disease is a potentially curable lymphoma with distinct histology, biologic behavior, and clinical characteristics. Outline potential strategies to consider when developing treatment plans for patients with hodgkin lymphoma, including prognostic markers and sequence of treatment. Using raw clinical data from the national comprehensive cancer network nccn database collected during the rituximab era, we built an enhanced ipi with the goal of improving risk. The national comprehensive cancer network nccn makes no representations or. Nccn guidelines insights hodgkin lymphoma, version 1.
What are the nccn guidelines for determining unfavorable. The nccn templates are not exhaustive and do not represent the full spectrum of care or treatment options described in the nccn guidelines or the nccn compendium or include all appropriate approaches or combinations of drugs or biologics for the treatment of cancer. After someone is diagnosed with hodgkin lymphoma hl, doctors will try to figure out if it has spread, and if so, how far. A predictive model for aggressive non hodgkin s lymphoma. Nccn believes that the best management of any cancer patient is in a clinical trial.
These guidelines were developed for more common nhl histologic types, including chronic lymphocytic leukemiasmall lymphocytic lymphoma, follicular lymphoma, and diffuse large bcell lymphoma, and for less common entities with unique natural histories and therapies, such as marginal zone lymphoma, mantle cell lymphoma, and highly aggressive. The who classification divides hl into 2 main types. The nccn clinical practice guidelines in oncology for hodgkin lymphoma hl provide recommendations for the management of adult patients with hl. Nccn updates hodgkins disease treatment guidelines. Hodgkin lymphoma is a rare but highly curable cancer of the lymph nodes and the lymphatic system. Hodgkin lymphoma nccn hodgkin lymphoma panel members summary of guidelines updates diagnosis and workup hodg1 cs iaiia favorable hodg2. Pdf this portion of the nccn guidelines for hodgkin lymphoma hl focuses on the management of classical hl. Nccn guidelines for patients hodgkin lymphoma 2019. Given the myriad of treatment options available for frontline treatment of advancedstage hodgkin lymphoma hl and for relapsed hl, clinicians must evaluate the advantages and disadvantages of each regimen, balancing risk with benefit for the individual patient at the nccn 2019 annual congress. The stage of a cancer describes how much cancer is in the body.